PathMD Quizes, Anatomic

Anatomic – 04

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1. A cystoscopy was performed on a 70-year-old male who was found to have a marbled to golf ball sized lesion in the bladder. A transurethral resection was performed, and the slides along with the appropriate immunohistochemical stains are shown. Based on the findings, what is the best diagnosis?

Bladder Small Cell Carcinoma
H&E section of the bladder tumor–medium power


Bladder - Small Cell Carcinoma
H&E section of bladder tumor-high power.


CD56 - Bladder Small Cell
CD56 expression in the tumor cells.


GATA-3 Bladder Small Cell Carcinoma
GATA-3 expression in the tumor cells.


Synaptophysin-bladder small cell carcinoma
TTF-1-Bladder Small Cell Carcinoma
TTF-1 expression in the tumor cells.
2. A 70-year-old male undergo cystoscopy for intermittent hematuria. Based on the histologic findings in the images below, what is the best diagnosis?

Bladder Tumor-High-Grade Papillary Urothelial Carcinoma
Low power


Bladder Tumor-High-Grade Papillary Urothelial Carcinoma
Medium power


Bladder Tumor-High-Grade Papillary Urothelial Carcinoma
High power
3. A 50 year old male presents with a breast mass.  Based on the following images representative of the histology and immunohistochemistry, what is the best diagnosis?

Myofibroblastoma of breastMyofibroblastoma of breast
Myofibroblastoma - CD34
CD34 expression


Myofibroblastoma - Desmin
Desmin
4. A 65 year old male is noted to have a retroperitoneal mass by imaging.  Based on the morphology and images below, what is the best diagnosis?

Renal Cell Carcinoma - H&E
H&E


Renal Cell Carcinoma - CK7
CK7


Renal Cell Carcinoma - CK7
CK20


Renal Cell Carcinoma - HepPar-1
HepPar-1


Renal Cell Carcinoma - Vimentin
Vimentin
5. Which of the following is the most common location for metastatic neoplasms?