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JAK2, CALR, & MPL Testing in Myeloproliferative Neoplasms (MPN)

Molecular Testing Specimen Adequacy Summary
  • JAK2, CALR, and MPL testing is often performed on peripheral blood specimens in an outpatient setting.
  • JAK2 mutations are preferably analyzed in granulocytes.
  • Peripheral blood and bone marrow specimens are equally adequate for the identification of JAK2 mutations.
  • By extrapolation, CALR and MPL testing on peripheral blood specimens should be equally adequate.

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