PathMD Quizes, GU Pathology GU Pathology – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. All of the following parameters are associated with adverse outcome in prostatic carcinoma, EXCEPT:Positive surgical marginsExtraprostatic extensionInvolvement of seminal vesicle Nodal metastases Perineural invasion 2. A 3 year old boy presents with a large abdominal mass consistent with neuroblastoma. All of the following statements regarding this condition are correct, EXCEPT:Hemorrhage, calcification and necrosis are common macroscopic features Two characteristic genetic events are loss of a distal region of chromosome 1p and amplification of N-myc oncogene Over 80% are detected in children under the age of 4 It is associated with the Beckwith-Wiedemann syndrome, Hirschsprung's disease and neurofibromatosisHistologically, the most prominent feature is presence of Homer Wright rosettes 3. If seen on a prostate core biopsy this prostatic adenocarcinoma would be best graded as Gleason score =3 for 60%, Gleason score = 4 for 25%, and Gleason score = 5 for 15%. How would the case be scored overall?Gleason score 3 + 4 = 7/10 Gleason score 5 + 3 = 8/10 Gleason score 3 + 5 = 8/10 Gleason score 3 + 3 = 6/10 Gleason score 4 + 5 = 9/10 4. The following statements regarding normal prostate are true, EXCEPT:Anterior fibromuscular stroma occupies approximately 1/3 of the prostate, contains very few glands and consists of smooth muscle and dense fibrous tissue Denonvillier's fascia separates the prostate and seminal vesicles from the rectum Skeletal muscle of the urogenital diaphragm extends into the prostate in its most apical aspectLarge number of neuroendocrine cells are present in prostatic epitheliumLipofuscin pigment helps differentiate seminal vesicle tissue from prostatic glands 5. This subtype of prostatic carcinoma overall has a better prognosis than the usual acinar type:Ductal carcinomaAdenoid basal cell tumor (adenoid cystic tumor)Signet ring carcinoma Small cell carcinomaMucinous adenocarcinoma 6. All of the statements concerning a fibroepithelial polyp of the bladder are true, EXCEPT:It is mostly found in children and young adults This lesion has no malignant potential There is a female predominanceIt occurs most commonly at the ureteropelvic junction and upper ureter It represents a mesenchymal tumor 7. 63 year old male with a history of bilateral ocular MALT lymphoma treated with radiation therapy. He now presents with diffuse pelvic infiltrative process involving the bladder, prostate, seminal vesicles, rectosigmoid, distal ureters, and adjacent muscles. Bladder and prostate biopsies were performed. Based on histology, the process is most consistent with:High grade prostatic adenocarcinoma Invasive transitional cell carcinoma (urothelial neoplasm) Idiopathic retroperitoneal fibrosis High-grade lymphoma Recurrent MALT lymphoma 8. All of the following statements are correct regarding this kidney neoplasm, EXCEPT: GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5It always has three components: undifferentiated blastema, mesenchymal tissue and epithelial tissueStaging is the most important prognostic determinator 90% of the cases occur before the age of 6 It is associated with Beckwith-Wiedemann and Denys-Drash syndromes Lesions are divided into favorable and unfavorable histology groups based on the degree of anaplasia 9. A 42 yo female presented with hypertension, Cushing's syndrome and virilization. A representative section from her resection specimen is consistent with an adrenal cortical carcinoma. All of the following features are part of diagnostic criteria for this tumor EXCEPT:Tumor weightDiffuse growth patternVascular invasionTumor necrosis Cellular pleomorphism Loading...
