PathMD Quizes, GU Pathology GU Pathology – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. The following statements regarding normal prostate are true, EXCEPT:Large number of neuroendocrine cells are present in prostatic epitheliumAnterior fibromuscular stroma occupies approximately 1/3 of the prostate, contains very few glands and consists of smooth muscle and dense fibrous tissue Denonvillier's fascia separates the prostate and seminal vesicles from the rectum Lipofuscin pigment helps differentiate seminal vesicle tissue from prostatic glands Skeletal muscle of the urogenital diaphragm extends into the prostate in its most apical aspect 2. A 42 yo female presented with hypertension, Cushing's syndrome and virilization. A representative section from her resection specimen is consistent with an adrenal cortical carcinoma. All of the following features are part of diagnostic criteria for this tumor EXCEPT:Vascular invasionDiffuse growth patternTumor necrosis Tumor weightCellular pleomorphism 3. A 3 year old boy presents with a large abdominal mass consistent with neuroblastoma. All of the following statements regarding this condition are correct, EXCEPT:Hemorrhage, calcification and necrosis are common macroscopic features Two characteristic genetic events are loss of a distal region of chromosome 1p and amplification of N-myc oncogene Histologically, the most prominent feature is presence of Homer Wright rosettesOver 80% are detected in children under the age of 4 It is associated with the Beckwith-Wiedemann syndrome, Hirschsprung's disease and neurofibromatosis 4. All of the statements concerning a fibroepithelial polyp of the bladder are true, EXCEPT:It represents a mesenchymal tumor It occurs most commonly at the ureteropelvic junction and upper ureter This lesion has no malignant potential There is a female predominanceIt is mostly found in children and young adults 5. This subtype of prostatic carcinoma overall has a better prognosis than the usual acinar type:Ductal carcinomaMucinous adenocarcinoma Adenoid basal cell tumor (adenoid cystic tumor)Signet ring carcinoma Small cell carcinoma 6. If seen on a prostate core biopsy this prostatic adenocarcinoma would be best graded as Gleason score =3 for 60%, Gleason score = 4 for 25%, and Gleason score = 5 for 15%. How would the case be scored overall?Gleason score 3 + 5 = 8/10 Gleason score 5 + 3 = 8/10 Gleason score 3 + 3 = 6/10 Gleason score 4 + 5 = 9/10 Gleason score 3 + 4 = 7/10 7. All of the following parameters are associated with adverse outcome in prostatic carcinoma, EXCEPT:Extraprostatic extensionPositive surgical marginsInvolvement of seminal vesicle Nodal metastases Perineural invasion 8. All of the following statements are correct regarding this kidney neoplasm, EXCEPT: GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5 GU Pathology - Part 1, Case #5Lesions are divided into favorable and unfavorable histology groups based on the degree of anaplasia 90% of the cases occur before the age of 6 Staging is the most important prognostic determinator It always has three components: undifferentiated blastema, mesenchymal tissue and epithelial tissueIt is associated with Beckwith-Wiedemann and Denys-Drash syndromes 9. 63 year old male with a history of bilateral ocular MALT lymphoma treated with radiation therapy. He now presents with diffuse pelvic infiltrative process involving the bladder, prostate, seminal vesicles, rectosigmoid, distal ureters, and adjacent muscles. Bladder and prostate biopsies were performed. Based on histology, the process is most consistent with:Recurrent MALT lymphoma Idiopathic retroperitoneal fibrosis High grade prostatic adenocarcinoma High-grade lymphoma Invasive transitional cell carcinoma (urothelial neoplasm) Loading...
