|
Tumor
|
||
|
TCC (Urothelial)
|
+
|
+
|
|
Ovarian Ca. (mucinous)
|
+
|
+
|
|
Pancreatic Ca. (subset)
|
+
|
+
|
|
Cholangiocarcinoma (subset)
|
+
|
+
|
|
Gastric Adenoca. (subset)
|
+
|
+
|
|
Sm. Int. (non-Ampullary) Ca.
|
+
|
+ (60-70%)
|
Follow-up Markers for CK7+/CK20+
|
IHC Stain
|
Comment
|
|
Uroplakin
|
Supportive of urothelial carcinoma
|
|
Thrombomodulin
|
Expression may be seen in urothelial carcinoma or adenocarcinoma of the bladder
|
|
Expression supports urothelial carcinoma
|
|
|
CK5/6
|
Expression supports urothelial carcinoma
|
|
May be supportive of pancreatic ductal carcinoma
|
|
|
CA19-9
|
May be supportive of pancreatic ductal carcinoma
|
|
+/- expression seen in pancreatic ductal carcinoma, adenocarcinoma of the bladder, and ovarian mutinous carcinoma
|
|
|
Expression supports urothelial carcinoma
|
References
Arch Pathol Lab Med. Vol 134, February 2010.
Hadi, AIMM Annual Meeting, “Carcinomas of Unknown Primary”, presentation, 2011.