|
Tumor
|
||
|
Breast Ca. (>95%)
|
+
|
= (0-16%+)
|
|
Lung Adenoca. (90%)
|
+
|
=
|
|
Ovarian Ca. (Serous) (>90%)
|
+
|
=
|
|
Pancreatic Ca. (Subset)
|
+
|
=
|
|
Mesothelioma
|
+
|
=
|
|
Endometrial Adenoca.
|
+
|
=
|
|
Lung Small Cell Ca. (60-80%)
|
+ (dot-like)
|
=
|
|
Cholangiocarcinoma
|
+
|
=
|
|
Thyroid Carcinoma
|
+
|
=
|
|
Gastric Carcinoma (subset)
|
+
|
=
|
Follow-up Markers CK7+/CK20=
|
Expression seen in lung adenocarcinoma, small cell carcinoma, and thyroid carcinoma (medullary, papillary and follicular)
|
|
|
Expression commonly seen in lung adenoma., but not mesothelioma.
|
|
|
CK5/6
|
Expression commonly seen in mesothelioma, but NOT lung adenoca.
|
|
Expression supports neuroendocrine origin or differentiation (small cell carcinoma). Medullary thyroid ca. is also positive.
|
|
|
Expression Supports neuroendocrine origin or differentiation (small cell carcinoma). Medullary thyroid ca. is also positive.
|
|
|
Expression may be seen in breast carcinoma, ovarian serous carcinoma, and endometrial adenocaricnoma.
|
|
|
Expression is fairly specific for breast carcinoma.
|
|
|
Mammaglobin
|
Expression is fairly specific for breast carcinoma.
|
|
Expression is often seen in mesothelioma and ovarian serous carcinomas.
|
|
|
Expression may be seen in cholangiocarcinoma, breast carcinoma, and lung adenocarcinoma. Expression is NOT usually seen in ovarian serous carcinoma, endometrial adenocarcinoma, or mesothelioma.
|
|
|
Specific marker for follicular and papillary thyroid carcinoma. Medullary ca. does not express Thyroglobulin.
|
|
|
Expression usually found in mesothelioma.
|
|
|
Expression is typical for medullary (thyroid) ca.
|
References
Arch Pathol Lab Med. Vol 134, February 2010.
Hadi, AIMM Annual Meeting, “Carcinomas of Unknown Primary”, presentation, 2011.