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Dyserythrpoiesis

Karyorrhexis

Karyorrhexis of erythroid precursors is refined as a pyknotic nucleus with nuclear (destructive) fragmentation (an abnormal form of apoptosis) that results in cell death.

Dyserythropoiesis - Karyorrhexis
Karyorrhexis of erythroid precursor. Note the nuclear fragmentation and irregular spacing of the nuclear fragments.
Dyserythropoiesis - Karyorrhexis
Karyorrhexis of erythroid precursor.
Dyserythropoiesis - Karyorrhexis
Karyorrhexis of erythroid precursor.
Nuclear Budding
Dyserythropoiesis - Nuclear Budding
Nuclear budding (may also be undergoing karyorrhexis).
Erythroid precursor containing nuclear membrane irregularity and early budding.
Mutlinucleation
Dyserythropoiesis - Multinucleated erythorid precursor
Immature erythroid precursor with multinucleation.
Vacuolated Erythroid Precursors
Vacuolated Erythroid Precursor
Vacuolated Erythroid Precursor – Bone marrow from a 39 y/o female with zinc toxicity induced copper deficiency.
Ring Sideroblasts
Ring Sideroblasts (Iron Stain)
Erythroid precursors with ring sideroblasts (iron stain)
References

Zhou T, Kinney MC, Scott LM, Zinkel SS, Rebel VI. Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research. Blood. 2015;126: 1057–1068. doi:10.1182/blood-2015-01-624239

Swerdlow SH, Campo E, Harris, NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):  WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition). IARC: Lyon 2017