1. Which of the following characteristics is the most important defining feature of AML-M0?

2. A cervical lymph node is biopsied from a 25 y/o man. Representative histology from the lymph node is shown. Based on the findings, what is the expected immunohistochemistry profile?

3. A 50-year-old male presents with mild splenomegaly and circulating atypical lymphocytes. Flow cytometry identifies a CD20 positive, CD5 and CD10 negative kappa restricted lymphoid population. Based on the morphologic and flow cytometry findings, which of the following is the best diagnosis?

4. Based on the morphologic findings of the peripheral blood smear for this question, which of the following is the best diagnosis?

5. Which of the following characteristics is the most important defining feature of AML-M2?

6. A 40 y/o man presents with isolated inguinal lymphadenopathy. An excisional biopsy is performed. Representative sections and special stains are shown. Based on the findings, what is the best diagnosis?

7. A soft tissue mass is found in the breast of a 45 y/o female that was thought to probably represent breast carcinoma. Representative images are shown. The histiocytic cells are positive for S-100 and negative for CD1a. Based on the findings, what is the best diagnosis?

8. AML-M3 is characterized by?

9. A 50 y/o male presents with nasal obstruction. A biopsy is performed and representative sections are shown. The cells of interest are positive for CD56 and EBV by in situ hybridization (EBER). Based on these findings, what is the best diagnosis?

10. Which of the following characteristics is the most important defining feature of AML-M1?