PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following statements best describes rheumatoid factor?IgA rheumatoid factor is associated with less severe diseaseIt is an antibody against the Fab portion of IgGThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueTest methodology is typically nephelometry or latex immunofixationIt is an antibody against cellular DNA 2. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesHeterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)Anti-CMV IgG present in the patient’s serum confirms acute CMV infection IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionAn anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis 3. The HLA gene is present at which chromosomal location?22q6p 6q3q3p 4. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area III has bivalent binding capacityArea II represents the carboxy terminusArea IV is a crystallizable fragment Area V is the site of pepsin cleavageArea III represents the constant domain 5. Which one of the following disease-HLA associations is incorrect?Rheumatoid arthritis – DR4Sjogren syndrome – DR3Ankylosing spondylitis – B27Goodpasture’s disease – B35Type I diabetes mellitus – DR3, DR4 6. Which disease-hypersensitivity type association is incorrect?Bee sting allergy – immediate (type I)Systemic lupus erythematosus -- immune complex-mediated (type III) Transplant rejection – cell-mediated (type IV) Serum sickness – antibody-mediated (type II)Goodpasture syndrome -- antibody-mediated (type II) 7. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Thymic aplasiaDeletions on chromosome 11q22 Cardiac abnormalitiesHypocalcemia Cleft palate 8. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, III, IVII, III, IVAll of the above I, II, IVI, II, III 9. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1properdinC3 convertaseC1 inhibitorC4 10. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI, II, IVI onlyI and II onlyI, II, IIIAll of the above 11. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?A serum specimen must be run concurrently for comparisonSilver staining is more rapid, but less sensitive than Coomassie BlueOligoclonal bands are found in the beta-2 regionOligoclonal bands are pathognomonic for MS Typically performed by SDS-PAGE 12. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1This pattern is consistent with nephrotic syndromePeak V is consistent with a polyclonal gammopathyNone are correctHaptoglobin is normally a component of peak IIPeak I is the closest peak to the cathode 13. Which one of the following statements regarding IgD is false?About 1% of all serum immunoglobulins Binds complement Does not cross the placenta Does not bind to cells through its Fc region 14. Which one of the following statements regarding complement C3 is incorrect?Predominantly produced by the hepatocytePart of the membrane attack complex (MAC) Deficiencies are associated with increased risk of meningococcal infection Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisEnzymatic cleavage yields an anaphylatoxin and an opsonin Loading... Share this:TwitterWhatsAppFacebookEmailPrintLinkedIn Related
