PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1properdinC4C3 convertaseC1 inhibitor 2. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Silver staining is more rapid, but less sensitive than Coomassie BlueOligoclonal bands are pathognomonic for MS A serum specimen must be run concurrently for comparisonOligoclonal bands are found in the beta-2 regionTypically performed by SDS-PAGE 3. Which disease-hypersensitivity type association is incorrect?Serum sickness – antibody-mediated (type II)Systemic lupus erythematosus -- immune complex-mediated (type III) Transplant rejection – cell-mediated (type IV) Goodpasture syndrome -- antibody-mediated (type II) Bee sting allergy – immediate (type I) 4. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Thymic aplasiaHypocalcemia Cardiac abnormalitiesDeletions on chromosome 11q22 Cleft palate 5. Which one of the following statements regarding IgD is false?About 1% of all serum immunoglobulins Does not cross the placenta Does not bind to cells through its Fc region Binds complement 6. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, III, IVI, II, III II, III, IVI, II, IVAll of the above 7. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI and II onlyI, II, IIII onlyAll of the aboveI, II, IV 8. The HLA gene is present at which chromosomal location?6p 22q3q6q3p 9. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Haptoglobin is normally a component of peak IIPeak I is the closest peak to the cathode This pattern is consistent with nephrotic syndromePeak V is consistent with a polyclonal gammopathyNone are correct 10. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?Heterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesAnti-CMV IgG present in the patient’s serum confirms acute CMV infection IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionAn anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis 11. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area II represents the carboxy terminusArea III has bivalent binding capacityArea III represents the constant domain Area V is the site of pepsin cleavageArea IV is a crystallizable fragment 12. Which one of the following disease-HLA associations is incorrect?Sjogren syndrome – DR3Goodpasture’s disease – B35Rheumatoid arthritis – DR4Ankylosing spondylitis – B27Type I diabetes mellitus – DR3, DR4 13. Which one of the following statements best describes rheumatoid factor?It is an antibody against the Fab portion of IgGTest methodology is typically nephelometry or latex immunofixationIt is an antibody against cellular DNAThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueIgA rheumatoid factor is associated with less severe disease 14. Which one of the following statements regarding complement C3 is incorrect?Predominantly produced by the hepatocyteEnzymatic cleavage yields an anaphylatoxin and an opsonin Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisDeficiencies are associated with increased risk of meningococcal infection Part of the membrane attack complex (MAC) Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related
