PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsAll of the above I, III, IVII, III, IVI, II, IVI, II, III 2. The HLA gene is present at which chromosomal location?3q22q6q3p6p 3. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Peak I is the closest peak to the cathode Peak V is consistent with a polyclonal gammopathyThis pattern is consistent with nephrotic syndromeNone are correctHaptoglobin is normally a component of peak II 4. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Typically performed by SDS-PAGE Silver staining is more rapid, but less sensitive than Coomassie BlueA serum specimen must be run concurrently for comparisonOligoclonal bands are found in the beta-2 regionOligoclonal bands are pathognomonic for MS 5. Which one of the following statements regarding complement C3 is incorrect?Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisPredominantly produced by the hepatocyteEnzymatic cleavage yields an anaphylatoxin and an opsonin Part of the membrane attack complex (MAC) Deficiencies are associated with increased risk of meningococcal infection 6. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaAll of the aboveI, II, IIII and II onlyI, II, IVI only 7. Which one of the following statements best describes rheumatoid factor?IgA rheumatoid factor is associated with less severe diseaseIt is an antibody against cellular DNAIt is an antibody against the Fab portion of IgGThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueTest methodology is typically nephelometry or latex immunofixation 8. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionAnti-CMV IgG present in the patient’s serum confirms acute CMV infection Heterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytes 9. Which one of the following disease-HLA associations is incorrect?Ankylosing spondylitis – B27Sjogren syndrome – DR3Type I diabetes mellitus – DR3, DR4Goodpasture’s disease – B35Rheumatoid arthritis – DR4 10. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Cleft palate Deletions on chromosome 11q22 Hypocalcemia Cardiac abnormalitiesThymic aplasia 11. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area III has bivalent binding capacityArea II represents the carboxy terminusArea IV is a crystallizable fragment Area V is the site of pepsin cleavageArea III represents the constant domain 12. Which one of the following statements regarding IgD is false?Binds complement Does not bind to cells through its Fc region About 1% of all serum immunoglobulins Does not cross the placenta 13. Which disease-hypersensitivity type association is incorrect?Transplant rejection – cell-mediated (type IV) Systemic lupus erythematosus -- immune complex-mediated (type III) Bee sting allergy – immediate (type I)Serum sickness – antibody-mediated (type II)Goodpasture syndrome -- antibody-mediated (type II) 14. Which one of the listed factors from the complement system is deficient in hereditary angioedema?properdinC3 convertaseC1 inhibitorC4C1 Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related
