PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following statements regarding complement C3 is incorrect?Enzymatic cleavage yields an anaphylatoxin and an opsonin Predominantly produced by the hepatocyteDeficiencies are associated with increased risk of meningococcal infection Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisPart of the membrane attack complex (MAC) 2. Which one of the following statements best describes rheumatoid factor?The test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueIt is an antibody against the Fab portion of IgGIt is an antibody against cellular DNATest methodology is typically nephelometry or latex immunofixationIgA rheumatoid factor is associated with less severe disease 3. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?A serum specimen must be run concurrently for comparisonOligoclonal bands are pathognomonic for MS Typically performed by SDS-PAGE Oligoclonal bands are found in the beta-2 regionSilver staining is more rapid, but less sensitive than Coomassie Blue 4. Which one of the following disease-HLA associations is incorrect?Rheumatoid arthritis – DR4Goodpasture’s disease – B35Ankylosing spondylitis – B27Type I diabetes mellitus – DR3, DR4Sjogren syndrome – DR3 5. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?Anti-CMV IgG present in the patient’s serum confirms acute CMV infection An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionLymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesHeterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA) 6. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Cleft palate Hypocalcemia Deletions on chromosome 11q22 Cardiac abnormalitiesThymic aplasia 7. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsII, III, IVI, III, IVI, II, III I, II, IVAll of the above 8. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI, II, IVI and II onlyI onlyAll of the aboveI, II, III 9. The HLA gene is present at which chromosomal location?6q22q3p3q6p 10. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1None are correctPeak I is the closest peak to the cathode This pattern is consistent with nephrotic syndromeHaptoglobin is normally a component of peak IIPeak V is consistent with a polyclonal gammopathy 11. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area III represents the constant domain Area II represents the carboxy terminusArea IV is a crystallizable fragment Area III has bivalent binding capacityArea V is the site of pepsin cleavage 12. Which one of the following statements regarding IgD is false?About 1% of all serum immunoglobulins Does not bind to cells through its Fc region Binds complement Does not cross the placenta 13. Which disease-hypersensitivity type association is incorrect?Bee sting allergy – immediate (type I)Transplant rejection – cell-mediated (type IV) Serum sickness – antibody-mediated (type II)Systemic lupus erythematosus -- immune complex-mediated (type III) Goodpasture syndrome -- antibody-mediated (type II) 14. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C1C1 inhibitorC4C3 convertaseproperdin Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related
