PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following statements regarding IgD is false?Binds complement Does not cross the placenta About 1% of all serum immunoglobulins Does not bind to cells through its Fc region 2. Which one of the following disease-HLA associations is incorrect?Rheumatoid arthritis – DR4Ankylosing spondylitis – B27Sjogren syndrome – DR3Type I diabetes mellitus – DR3, DR4Goodpasture’s disease – B35 3. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area II represents the carboxy terminusArea V is the site of pepsin cleavageArea IV is a crystallizable fragment Area III represents the constant domain Area III has bivalent binding capacity 4. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Hypocalcemia Cardiac abnormalitiesThymic aplasiaDeletions on chromosome 11q22 Cleft palate 5. The HLA gene is present at which chromosomal location?3p6q3q22q6p 6. Which disease-hypersensitivity type association is incorrect?Goodpasture syndrome -- antibody-mediated (type II) Transplant rejection – cell-mediated (type IV) Systemic lupus erythematosus -- immune complex-mediated (type III) Serum sickness – antibody-mediated (type II)Bee sting allergy – immediate (type I) 7. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1Peak V is consistent with a polyclonal gammopathyHaptoglobin is normally a component of peak IIPeak I is the closest peak to the cathode This pattern is consistent with nephrotic syndromeNone are correct 8. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, II, III All of the above II, III, IVI, II, IVI, III, IV 9. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Oligoclonal bands are found in the beta-2 regionA serum specimen must be run concurrently for comparisonOligoclonal bands are pathognomonic for MS Silver staining is more rapid, but less sensitive than Coomassie BlueTypically performed by SDS-PAGE 10. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Anti-CMV IgG present in the patient’s serum confirms acute CMV infection IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionHeterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytes 11. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C4properdinC1C1 inhibitorC3 convertase 12. Which one of the following statements regarding complement C3 is incorrect?Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisDeficiencies are associated with increased risk of meningococcal infection Part of the membrane attack complex (MAC) Predominantly produced by the hepatocyteEnzymatic cleavage yields an anaphylatoxin and an opsonin 13. Which one of the following statements best describes rheumatoid factor?It is an antibody against the Fab portion of IgGIgA rheumatoid factor is associated with less severe diseaseThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueTest methodology is typically nephelometry or latex immunofixationIt is an antibody against cellular DNA 14. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI onlyAll of the aboveI, II, IIII, II, IVI and II only Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related
