PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which one of the following statements regarding IgD is false?Binds complement Does not bind to cells through its Fc region Does not cross the placenta About 1% of all serum immunoglobulins 2. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Oligoclonal bands are found in the beta-2 regionTypically performed by SDS-PAGE Silver staining is more rapid, but less sensitive than Coomassie BlueOligoclonal bands are pathognomonic for MS A serum specimen must be run concurrently for comparison 3. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1This pattern is consistent with nephrotic syndromePeak I is the closest peak to the cathode Haptoglobin is normally a component of peak IINone are correctPeak V is consistent with a polyclonal gammopathy 4. Which one of the following statements regarding complement C3 is incorrect?Predominantly produced by the hepatocytePart of the membrane attack complex (MAC) Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosisDeficiencies are associated with increased risk of meningococcal infection Enzymatic cleavage yields an anaphylatoxin and an opsonin 5. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area V is the site of pepsin cleavageArea III has bivalent binding capacityArea II represents the carboxy terminusArea III represents the constant domain Area IV is a crystallizable fragment 6. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI, II, IIII, II, IVI and II onlyAll of the aboveI only 7. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, II, III I, III, IVAll of the above II, III, IVI, II, IV 8. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesAnti-CMV IgG present in the patient’s serum confirms acute CMV infection IgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infectionHeterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA) 9. Which disease-hypersensitivity type association is incorrect?Goodpasture syndrome -- antibody-mediated (type II) Transplant rejection – cell-mediated (type IV) Systemic lupus erythematosus -- immune complex-mediated (type III) Bee sting allergy – immediate (type I)Serum sickness – antibody-mediated (type II) 10. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Hypocalcemia Deletions on chromosome 11q22 Cardiac abnormalitiesThymic aplasiaCleft palate 11. Which one of the following statements best describes rheumatoid factor?Test methodology is typically nephelometry or latex immunofixationIgA rheumatoid factor is associated with less severe diseaseIt is an antibody against the Fab portion of IgGIt is an antibody against cellular DNAThe test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive value 12. Which one of the following disease-HLA associations is incorrect?Type I diabetes mellitus – DR3, DR4Goodpasture’s disease – B35Ankylosing spondylitis – B27Sjogren syndrome – DR3Rheumatoid arthritis – DR4 13. The HLA gene is present at which chromosomal location?3p6q3q6p 22q 14. Which one of the listed factors from the complement system is deficient in hereditary angioedema?properdinC1 inhibitorC1C3 convertaseC4 Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related
