PathMD Quizes, Clinical Immunology – 01 October 29, 2017 peferguson Author: Greg McKenzie, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following hold antigen-antibody complexes together? I. electrostatic forces II. covalent bonds III. van der Waals forces IV. hydrophobic interactionsI, III, IVI, II, III All of the above I, II, IVII, III, IV 2. Which one of the following is not a characteristic component of DiGeorge’s syndrome?Thymic aplasiaDeletions on chromosome 11q22 Hypocalcemia Cardiac abnormalitiesCleft palate 3. Which one of the following statements regarding IgD is false?Binds complement Does not cross the placenta About 1% of all serum immunoglobulins Does not bind to cells through its Fc region 4. The HLA gene is present at which chromosomal location?3q6q6p 3p22q 5. (Please refer to the image below) Which one of the following statements regarding the serum protein electrophoresis pattern is correct? Immunology Set 1None are correctThis pattern is consistent with nephrotic syndromeHaptoglobin is normally a component of peak IIPeak I is the closest peak to the cathode Peak V is consistent with a polyclonal gammopathy 6. Which disease-hypersensitivity type association is incorrect?Goodpasture syndrome -- antibody-mediated (type II) Bee sting allergy – immediate (type I)Systemic lupus erythematosus -- immune complex-mediated (type III) Serum sickness – antibody-mediated (type II)Transplant rejection – cell-mediated (type IV) 7. A 20-year-old male presented with lethargy, fever, sore throat, and cervical lymphadenopathy. Physical examination revealed splenomegaly. Laboratory evaluation revealed lymphocytosis with large, atypical lymphocytes. Which of the following statements is correct?Heterophile antibodies are composed of a mixture of IgG and IgM antibodies specific for EBV early antigen (EA)An anti-streptolysin O (ASO) test is indicated to rule out a group B streptococcal pharyngitis Anti-CMV IgG present in the patient’s serum confirms acute CMV infection Lymph node biopsy is likely to reveal large, atypical, CD15 and CD30 positive lymphocytesIgM (titer > 1:32) to EBV viral core antigen (VCA) is consistent with acute EBV infection 8. Which one of the following disease-HLA associations is incorrect?Type I diabetes mellitus – DR3, DR4Ankylosing spondylitis – B27Sjogren syndrome – DR3Rheumatoid arthritis – DR4Goodpasture’s disease – B35 9. Which one of the listed factors from the complement system is deficient in hereditary angioedema?C4C1C1 inhibitorproperdinC3 convertase 10. Which one of the following statements regarding CSF electrophoresis in a patient with suspected multiple sclerosis (MS) is correct?Silver staining is more rapid, but less sensitive than Coomassie BlueOligoclonal bands are found in the beta-2 regionTypically performed by SDS-PAGE Oligoclonal bands are pathognomonic for MS A serum specimen must be run concurrently for comparison 11. Which one of the following statements regarding complement C3 is incorrect?Enzymatic cleavage yields an anaphylatoxin and an opsonin Predominantly produced by the hepatocyteDeficiencies are associated with increased risk of meningococcal infection Part of the membrane attack complex (MAC) Elevated levels in patients with idiopathic focal glomerulosclerosis indicates a favorable prognosis 12. Which one of the following statements best describes rheumatoid factor?The test is suitable for use as a screening test for rheumatoid arthritis among elderly patients due to its high positive predictive valueTest methodology is typically nephelometry or latex immunofixationIt is an antibody against cellular DNAIgA rheumatoid factor is associated with less severe diseaseIt is an antibody against the Fab portion of IgG 13. Which of the following conditions are associated with hyperviscosity? I. Waldenstrom’s macroglobulinemia II. Polycythemia vera III. Rheumatoid arthritis IV. Sickle cell anemiaI and II onlyI, II, IIII, II, IVAll of the aboveI only 14. (Please refer to the image below) Which one of the following statements is correct? Immunology Set 1Area IV is a crystallizable fragment Area III represents the constant domain Area V is the site of pepsin cleavageArea III has bivalent binding capacityArea II represents the carboxy terminus Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related
