PathMD Quizes, Renal Renal Neoplasms – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. An 18 y/o Caucasian male is found to have a renal tumor with clear cell RCC histology. It is important to perform cytogenetic analysis on this mass to look for involvement of which of the following chromosomes:3pXp11.2Chromosome 11p13 Chromosome 7None of the above 2. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorRenal Cell Carcinoma, Papillary Renal Cell Carcinoma, Conventional Renal Cell Carcinoma, ChromophobeOncocytomaNone of the above 3. This tumor from the kidney illustrated in images below was negative for S-100 and desmin. In other areas of the tumor, RCC marker was focally positive. Which of the following is the best diagnosis? Renal Tumor Renal TumorMetastatic malignant melanoma RCC, Fuhrman grade IV LeiomyomaNone of the above Rhabdomyosarcoma 4. A 5 cm mass is removed from a 41 y/o female which is found to have areas of smooth muscle cells, blood vessels, and fat. Special stains for HMB-45 were positive. This lesion is associated with all of the following conditions EXCEPT:Tuberous sclerosis Birt-Hogg-Dube syndrome von Hippel-Lindau (VHL) syndrome von Recklinghausen disease 5. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorRenal Cell Carcinoma, Papillary Renal Cell Carcinoma, Conventional None of the above Renal Cell Carcinoma, Chromophobe Oncocytoma 6. Which of the following result in the highest stage for a renal cell carcinoma according to the 2002 AJCC staging manual:Tumor directly invades adrenal gland Tumor grossly extends into the vena cava above the diaphragmMetastasis to one single regional lymph nodeTumor invades beyond Gerota’s fasciaTumor grossly invades the wall of the vena cava 7. The image below shows a renal tumor stained with Hale’s Colloidal Iron. The most likely diagnosis is: Renal Tumor Hale's Colloidal IronRCC, sarcomatoid type OncocytomaRCC, papillary type RCC, conventional type RCC, chromophobe type 8. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorRenal Cell Carcinoma, PapillaryNone of the aboveOncocytomaRenal Cell Carcinoma, ChromophobeRenal Cell Carcinoma, Conventional 9. An incidental renal lesion <1cm with papillary features and composed of predominantly clear cells is best classified as:Renal cell carcinoma, NOSRenal cell carcinoma, chromophil typeRenal cell carcinoma, clear cell type Papillary carcinomaPapillary adenoma 10. A renal tumor has predominantly clear cells with the highest grade area containing cells with irregular nuclear border (size ~20m) and nucleoli visible from 10X. Many of the cells are noted to have eccentrically placed nuclei and eosinophilic cytoplasm. The best Fuhrman grade is:Fuhrman grade IIFuhrman grade VFuhrman grade IIIFuhrman grade IFuhrman grade IV 11. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal Tumor Renal TumorNone of the above RhabdomyosarcomaWilm’s tumorMetanephric adenoma Renal cell carcinoma, papillary type 12. A 30 y/o African American male whose mother has sickle cell disease, is found to have a renal mass by CT examination. Which of the following are the most likely histologic features of this mass:Clear cells with abundant cytoplasm, irregular nuclei, and a fine network of thin walled vessels surrounding nests of cells. Reticular / yolk sac-like pattern with focal areas having an adenoid-cystic pattern. Tubular Mucinous Spindle cell RCC Tubulopapillary architecture of infiltrating cells some with a hobnail like appearance. Tumor cell nuclei are high grade. Papillary cores filled with foamy macrophages admixed with other areas of tubular and solid architecture. The cytoplasm is acidophilic, and no clear cell component is identified. 13. Which of the following is most helpful in differentiating chromophobe RCC from an oncocytoma:Granular cytoplasm BinucleationPerinuclear halosPleomorphism 14. According to the AJCC staging manual, all of the following affect the pathological staging of renal cell carcinoma EXCEPT:SizeFuhrman grade Extension into renal sinus fat Renal vein involvement Extension into perinephric fat Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related