PathMD Quizes, Renal Renal Neoplasms – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A 30 y/o African American male whose mother has sickle cell disease, is found to have a renal mass by CT examination. Which of the following are the most likely histologic features of this mass:Clear cells with abundant cytoplasm, irregular nuclei, and a fine network of thin walled vessels surrounding nests of cells. Papillary cores filled with foamy macrophages admixed with other areas of tubular and solid architecture. The cytoplasm is acidophilic, and no clear cell component is identified. Reticular / yolk sac-like pattern with focal areas having an adenoid-cystic pattern. Tubular Mucinous Spindle cell RCC Tubulopapillary architecture of infiltrating cells some with a hobnail like appearance. Tumor cell nuclei are high grade. 2. Which of the following is most helpful in differentiating chromophobe RCC from an oncocytoma:PleomorphismBinucleationPerinuclear halosGranular cytoplasm 3. An 18 y/o Caucasian male is found to have a renal tumor with clear cell RCC histology. It is important to perform cytogenetic analysis on this mass to look for involvement of which of the following chromosomes:Xp11.2Chromosome 11p13 3pNone of the aboveChromosome 7 4. A renal tumor has predominantly clear cells with the highest grade area containing cells with irregular nuclear border (size ~20m) and nucleoli visible from 10X. Many of the cells are noted to have eccentrically placed nuclei and eosinophilic cytoplasm. The best Fuhrman grade is:Fuhrman grade IVFuhrman grade VFuhrman grade IIFuhrman grade IFuhrman grade III 5. Which of the following result in the highest stage for a renal cell carcinoma according to the 2002 AJCC staging manual:Tumor invades beyond Gerota’s fasciaMetastasis to one single regional lymph nodeTumor grossly extends into the vena cava above the diaphragmTumor grossly invades the wall of the vena cava Tumor directly invades adrenal gland 6. A 5 cm mass is removed from a 41 y/o female which is found to have areas of smooth muscle cells, blood vessels, and fat. Special stains for HMB-45 were positive. This lesion is associated with all of the following conditions EXCEPT:von Recklinghausen disease von Hippel-Lindau (VHL) syndrome Tuberous sclerosis Birt-Hogg-Dube syndrome 7. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorOncocytomaRenal Cell Carcinoma, ChromophobeRenal Cell Carcinoma, Conventional None of the aboveRenal Cell Carcinoma, Papillary 8. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorNone of the above OncocytomaRenal Cell Carcinoma, Conventional Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Chromophobe 9. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal Tumor Renal TumorWilm’s tumorMetanephric adenoma Renal cell carcinoma, papillary typeRhabdomyosarcomaNone of the above 10. This tumor from the kidney illustrated in images below was negative for S-100 and desmin. In other areas of the tumor, RCC marker was focally positive. Which of the following is the best diagnosis? Renal Tumor Renal TumorNone of the above RhabdomyosarcomaLeiomyomaMetastatic malignant melanoma RCC, Fuhrman grade IV 11. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorOncocytomaRenal Cell Carcinoma, ChromophobeRenal Cell Carcinoma, PapillaryNone of the aboveRenal Cell Carcinoma, Conventional 12. The image below shows a renal tumor stained with Hale’s Colloidal Iron. The most likely diagnosis is: Renal Tumor Hale's Colloidal IronOncocytomaRCC, chromophobe type RCC, papillary type RCC, sarcomatoid type RCC, conventional type 13. According to the AJCC staging manual, all of the following affect the pathological staging of renal cell carcinoma EXCEPT:SizeExtension into renal sinus fat Fuhrman grade Extension into perinephric fat Renal vein involvement 14. An incidental renal lesion <1cm with papillary features and composed of predominantly clear cells is best classified as:Papillary adenoma Renal cell carcinoma, chromophil typeRenal cell carcinoma, NOSPapillary carcinomaRenal cell carcinoma, clear cell type Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related