PathMD Quizes, Renal Renal Neoplasms – 02 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A renal tumor has predominantly clear cells with the highest grade area containing cells with irregular nuclear border (size ~20m) and nucleoli visible from 10X. Many of the cells are noted to have eccentrically placed nuclei and eosinophilic cytoplasm. The best Fuhrman grade is:Fuhrman grade IVFuhrman grade IIIFuhrman grade VFuhrman grade IIFuhrman grade I 2. A 30 y/o African American male whose mother has sickle cell disease, is found to have a renal mass by CT examination. Which of the following are the most likely histologic features of this mass:Clear cells with abundant cytoplasm, irregular nuclei, and a fine network of thin walled vessels surrounding nests of cells. Reticular / yolk sac-like pattern with focal areas having an adenoid-cystic pattern. Papillary cores filled with foamy macrophages admixed with other areas of tubular and solid architecture. The cytoplasm is acidophilic, and no clear cell component is identified. Tubular Mucinous Spindle cell RCC Tubulopapillary architecture of infiltrating cells some with a hobnail like appearance. Tumor cell nuclei are high grade. 3. An 18 y/o Caucasian male is found to have a renal tumor with clear cell RCC histology. It is important to perform cytogenetic analysis on this mass to look for involvement of which of the following chromosomes:Chromosome 11p13 Xp11.23pNone of the aboveChromosome 7 4. A 5 cm mass is removed from a 41 y/o female which is found to have areas of smooth muscle cells, blood vessels, and fat. Special stains for HMB-45 were positive. This lesion is associated with all of the following conditions EXCEPT:von Recklinghausen disease Birt-Hogg-Dube syndrome Tuberous sclerosis von Hippel-Lindau (VHL) syndrome 5. According to the AJCC staging manual, all of the following affect the pathological staging of renal cell carcinoma EXCEPT:Fuhrman grade Extension into perinephric fat SizeRenal vein involvement Extension into renal sinus fat 6. The image below shows a renal tumor stained with Hale’s Colloidal Iron. The most likely diagnosis is: Renal Tumor Hale's Colloidal IronRCC, conventional type RCC, sarcomatoid type RCC, chromophobe type OncocytomaRCC, papillary type 7. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorRenal Cell Carcinoma, ChromophobeNone of the aboveRenal Cell Carcinoma, Conventional Renal Cell Carcinoma, PapillaryOncocytoma 8. An incidental renal lesion <1cm with papillary features and composed of predominantly clear cells is best classified as:Renal cell carcinoma, NOSPapillary adenoma Renal cell carcinoma, chromophil typeRenal cell carcinoma, clear cell type Papillary carcinoma 9. Which of the following result in the highest stage for a renal cell carcinoma according to the 2002 AJCC staging manual:Metastasis to one single regional lymph nodeTumor grossly extends into the vena cava above the diaphragmTumor directly invades adrenal gland Tumor invades beyond Gerota’s fasciaTumor grossly invades the wall of the vena cava 10. This tumor from the kidney illustrated in images below was negative for S-100 and desmin. In other areas of the tumor, RCC marker was focally positive. Which of the following is the best diagnosis? Renal Tumor Renal TumorLeiomyomaMetastatic malignant melanoma RhabdomyosarcomaNone of the above RCC, Fuhrman grade IV 11. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorOncocytomaRenal Cell Carcinoma, Papillary None of the aboveRenal Cell Carcinoma, ChromophobeRenal Cell Carcinoma, Conventional 12. Which of the following is most helpful in differentiating chromophobe RCC from an oncocytoma:Granular cytoplasm Perinuclear halosPleomorphismBinucleation 13. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal Tumor Renal TumorRhabdomyosarcomaNone of the above Wilm’s tumorRenal cell carcinoma, papillary typeMetanephric adenoma 14. The best diagnosis for the renal mass illustrated in the images below is which of the following: Renal Tumor Renal Tumor Renal TumorRenal Cell Carcinoma, Conventional None of the above OncocytomaRenal Cell Carcinoma, Papillary Renal Cell Carcinoma, Chromophobe Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related