PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show abundant mitochondria EM will show abundant rough endoplasmic reticulum EM will show numerous premelanosomes EM will show numerous lysosomesEM will show cytoplasmic microvilli 2. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:Pulmonary adenocarcinomaProstate carcinoma Thyroid follicular carcinoma Breast adenocarcinoma Mesothelioma 3. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:Breast adenocarcinoma Thyroid follicular carcinoma GI adenocarcinoma Prostate carcinoma Mesothelioma 4. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2AdenocarcinomaSchwannomaMelanomaGranular Cell Tumor Plasmacytoma 5. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:EpendymomaLymphomaMeningiomaSchwannomaCarcinoma 6. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?Papillary ependymoma NeurocytomaMedulloblastomaClear cell sarcomaAlveolar soft part sarcoma 7. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5OncocytomaRenal Cell Carcinoma, clear cell typeGranular Cell Tumor Renal Cell Carcinoma, chromophobe type Melanoma 8. A specimen being prepared for electron microscopy should be fixed in:Mercury based fixativeGluteraldehydeBouin’sB5Zinc formalin 9. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4SchwannomaMeningiomaAdenocarcinomaSquamous Cell Carcinoma Lymphoma 10. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3SchwannomaAdenocarcinomaSquamous Cell Carcinoma MesotheliomaMelanoma 11. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:SchwannomaChoroid plexus tumorCarcinomaAstrocytomaEpendymoma 12. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?S-100 Hale’s colloidal ironCD138CD45Synaptophysin 13. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1Squamous Cell Carcinoma SchwannomaMesotheliomaAdenocarcinomaMelanoma Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related