PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:Choroid plexus tumorSchwannomaEpendymomaCarcinomaAstrocytoma 2. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:Thyroid follicular carcinoma MesotheliomaPulmonary adenocarcinomaProstate carcinoma Breast adenocarcinoma 3. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?Clear cell sarcomaPapillary ependymoma NeurocytomaAlveolar soft part sarcoma Medulloblastoma 4. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?SynaptophysinCD138CD45Hale’s colloidal ironS-100 5. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:GI adenocarcinoma Prostate carcinoma Breast adenocarcinoma MesotheliomaThyroid follicular carcinoma 6. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4LymphomaMeningiomaSchwannomaAdenocarcinomaSquamous Cell Carcinoma 7. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show numerous lysosomesEM will show cytoplasmic microvilli EM will show abundant rough endoplasmic reticulum EM will show numerous premelanosomes EM will show abundant mitochondria 8. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5Renal Cell Carcinoma, clear cell typeMelanomaOncocytomaGranular Cell Tumor Renal Cell Carcinoma, chromophobe type 9. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:EpendymomaMeningiomaCarcinomaSchwannomaLymphoma 10. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2MelanomaSchwannomaAdenocarcinomaPlasmacytomaGranular Cell Tumor 11. A specimen being prepared for electron microscopy should be fixed in:B5Mercury based fixativeZinc formalin GluteraldehydeBouin’s 12. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1Squamous Cell Carcinoma MesotheliomaSchwannomaAdenocarcinomaMelanoma 13. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3MelanomaSquamous Cell Carcinoma SchwannomaAdenocarcinomaMesothelioma Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related