PathMD Quizes, Anatomic Electron Microscopy – 01 October 29, 2017 peferguson Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. A biopsy from the tongue shows pseudoepitheliomatous hyperplasia with histiocyte like cells underneath, which contain a granular cytoplasm. A diagnosis is suspected and confirmed with S-100 positivity. Which of the following is true with regards to this tumor:EM will show abundant mitochondria EM will show cytoplasmic microvilli EM will show abundant rough endoplasmic reticulum EM will show numerous premelanosomes EM will show numerous lysosomes 2. Based on the findings in the images below for Case #2, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 2 Electron Microscopy Set 1 Case 2AdenocarcinomaGranular Cell Tumor PlasmacytomaSchwannomaMelanoma 3. EM of a CNS tumor showed intracellular lumens lined by microvilli with specialized junctions between cells and glial features. This is most conisistant with which of the following tumors:CarcinomaSchwannomaChoroid plexus tumorEpendymomaAstrocytoma 4. Based on the findings in the images below for Case 1, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1 Electron Microscopy Set 1 Case 1MelanomaAdenocarcinomaMesotheliomaSquamous Cell Carcinoma Schwannoma 5. EM of an undifferentiated tumor is noted to have long thin microvilli (height to width ~ 10:1). Which of the following tumors is this most consistent with:Prostate carcinoma Thyroid follicular carcinoma MesotheliomaPulmonary adenocarcinomaBreast adenocarcinoma 6. An undifferentiated tumor shows prominent profiles of rough endoplasmic reticulum. Which of the following markers would also be positive in this lesion?Hale’s colloidal ironSynaptophysinS-100 CD45CD138 7. EM of a CNS tumor shows prominent interdigitating processes without a basal lamina. There are well formed desmosome junctions and prominent cytoplasmic inclusions. These findings are most consistent with:SchwannomaEpendymomaMeningiomaLymphomaCarcinoma 8. Based on the findings in the image below for Case #5, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 5MelanomaRenal Cell Carcinoma, clear cell typeOncocytomaRenal Cell Carcinoma, chromophobe type Granular Cell Tumor 9. EM of an undifferentiated tumor shows microvilli with long filamentous core rootlets (electron dense). This finding suggests which diagnosis:Thyroid follicular carcinoma Breast adenocarcinoma Prostate carcinoma GI adenocarcinoma Mesothelioma 10. EM of a tumor shows rhomboid crystalline inclusions. Cytogenetics also showed a t(X;17). These findings are consistent with which of the following neoplasms?Alveolar soft part sarcoma Clear cell sarcomaPapillary ependymoma NeurocytomaMedulloblastoma 11. Based on the findings in the images below for Case #4, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 4 Electron Microscopy Set 1 Case 4LymphomaSchwannomaSquamous Cell Carcinoma MeningiomaAdenocarcinoma 12. Based on the findings in the images below for Case #3, which of the following is the best diagnosis? Electron Microscopy Set 1 Case 3 Electron Microscopy Set 1 Case 3SchwannomaAdenocarcinomaSquamous Cell Carcinoma MelanomaMesothelioma 13. A specimen being prepared for electron microscopy should be fixed in:Zinc formalin GluteraldehydeBouin’sMercury based fixativeB5 Loading... Share this: Share on X (Opens in new window) X Share on WhatsApp (Opens in new window) WhatsApp Share on Facebook (Opens in new window) Facebook Email a link to a friend (Opens in new window) Email Print (Opens in new window) Print Share on LinkedIn (Opens in new window) LinkedIn Related