Endocervical vs. Endometrial Adenocarcinoma
Endocervical and endometrial adenocarcinomas may be morphologically indistinguishable morphologically. The question often comes up as to whether a case represents an endometrial adenocarcinoma involving the cervix, or and endocervical adenocarcinoma involving the endometrium. The following antibodies may be helpful in such circumstances:
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Endocervical
Adenocarcinoma
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Endometrial
Adenocarcinoma
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Negative (7-8%+)
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Positive (70-93%)
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Positive (65-95%)
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Usually Negative
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Negative (4-20%+, 38% weak)
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Strong Positive (67-90%)
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Strong & Diffuse Positive (90-100%)
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Patchy Positive cells (~35%)
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HPV
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Positive (67%)
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Negative
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References
AJSP 2002;26:998
“Endocervical vs. Endometrial Adenocarcinoma: Update on Useful Immunohistochemical Markers.” RT Miller,The Focus ProPath Immunohistochemistry.” April 2003.