Mammaglobin is an antibody that marks breast duct-lobular epitheliam, salivary gland epithelium, & skin eccrine epithelium. In neoplastic tissue is may stain cases of breast carcinoma, salivary gland tumors, endocervical CIS, and endometiral carcinoma. GCDFP-15 performs a little better than mammaglobin, and may have a better specificity profile.
Medullary and metaplastic breast carcinomas do not appear to mark with mammaglobin (Reyes, et al.). Their study also demonstrated that 49% of ductal carcinomas (n=1005) expressed mammaglobin, and of the positive cases 62% had expression in <25% of the tumor cells. Only 15-25% of basal-like or unclassified triple negative breast carcinomas express mammaglobin. Luminal A and B tumors tend to show the highest chance of expression of mammaglobin (>75% in one study with limited numbers – Lewis, et al.)
|
Tumor
|
Positive (%)
|
N
|
|
Breast Carcinoma
|
48%
|
238
|
|
Endometrial Ca.
|
11-39%
|
9 & 59
|
|
HEENT SCC
|
0%
|
20
|
|
Thyroid (Pap.) Ca.
|
0%
|
8
|
|
Non-SmalL Cell Ca. (Lung)
|
0%
|
106
|
|
Stomach Adenoca.
|
0%
|
19
|
|
Colon Adenocarinoma
|
0%
|
16
|
|
Pancreatic Adenoca.
|
1%
|
67
|
|
Ovarian Ca. (Serous)
|
6%
|
80
|
|
Sweat Gland Carcinoma
|
40%
|
10
|
|
Endocervical Adenoca.
|
0%
|
9
|
|
Endocervical AIS
|
45%
|
11
|
|
Renal Cell Carcinoma
|
0%
|
40
|
|
Urothelial Carcionma
|
0%
|
37
|
References
Hadi Yaziji, AIMM Annual Meeting, “New Antibodies in Diagnostic Immunohistochemistry”, presentation, 2010.
Lewis GH, Subhawong AP, Nassar H, Vang R, Illei PB, Park BH, et al. Relationship between molecular subtype of invasive breast carcinoma and expression of gross cystic disease fluid protein 15 and mammaglobin. Am J Clin Pathol. 2011;135: 587–591. doi:10.1309/AJCPMFR6OA8ICHNH
Reyes C, Gomez-Fernandez C, Nadji M. Metaplastic and Medullary Mammary Carcinomas Do Not Express Mammaglobin. Am J Clin Pathol. 2012;137: 747–752. doi:10.1309/AJCP5W5SEZSEHUHE
Sasaki E et al. Mod Pathol 2007;20:208-214.
Bhargava R et al. AJCO 2007;127:103-113.