• Lobular Carcinoma

• Medullary Carcinoma

  • Pattern characteristic of BRCA1 associated carcinomas
    • 13% are medullary type
    • 60% have subset of medullary features
  • Well-circumscribed mass
    • Solid sheets of pleomorphic large cells containing prominent nucleoli In >75% of the mass
    • Frequent mitosis
    • Prominent lymphoplasmacytic inflammatory infiltrate surrounding and infiltrating the tumor
    • Pushing/non-infiltrating border
    • DCIS is minimal or absent
  • WHO recommends classifying tumor as “carcinomas with medullary features”

• Micropapillary Carcinoma

• Mucinous (colloid) carcinoma

• Tubular Carcinoma

• Papillary Carcinoma

• Secretory Carcinoma

• Inflammatory Carcinoma

  • Clinically present with breast erythema and thickening (peau d’orange)
  • Dermal lymphatics filled with tumor
  • 3-year survival rate 3-10%

• Neuroendocrine Tumors

  • Well-differentiated Neuroendocrine Tumor
  • Small Cell Carcinoma

References

Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015.