PathMD Quizes, Neuropathology Neuropathology – 01 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. Which of the following types of meningioma has the worst prognosis based on histological features?MetaplasticFibroblasticSecretoryRhabdoidChordoid 2. Based on this image, this process: Neuropathology - Part 1, Question #7Is primarily sporadicIs a specific form of viral encephalopathy Is highly contagious among medical personnel Is difficult to suspect due to ill-defined clinical picture Evolves within a span of decades, with eventual death 3. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process? Neuropathology - Part 1, Question #9Gross examination of the brain rarely provides any clues It presents with rapidly progressing dementiaMost common location for this finding is cerebellumThis feature is pathognomonic for this disease process Definitive diagnosis is by autopsy 4. Which of the following is correct regarding the central nervous system tumors?Supratentorial tumors are common in children Hematogenous spread is common in high grade tumors due to vascular proliferation Biologic behavior does not necessarily correlate with histologyMeningioma is the most common primary brain tumor The annual incidence is 2/100,000 for intracranial tumors 5. Which of the following is true regarding acute neuronal injury?Healing neurons can be identified as chromatolyticIt can be reversible if detected by brain biopsy Red neurons can be seen as early as 2 hours after injury Eosinophilic neuronal necrosis is the earliest light microscopic signIt represents the typical injury pattern associated with toxic-metabolic insults 6. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct? Neuropathology - Part 1, Question #8It is a dysmyelinating processIt is a rare disorder in this age groupIt most commonly involves basal ganglia It is characterized by multiple lesions of various agesPresents with typical initial neurological signs and symptoms 7. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image: Neuropathology - Part 1, Question #4Is an acute hemorrhage Is a remote intraparenchymal hematoma secondary to traumaAn organized abscess cavity Is a remote infarct with hemorrhagic component Is encephalomalacia due to trauma 8. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:Is the result of an acute intoxicationPredominantly affects granule cell layerCan lead to cerebellar dysfunction in about 20% of casesIs the result of chronic methanol intoxication Is reversible with intensive therapy 9. Which of the following cell types originate outside the central nervous system?AstrocytesNeurons of the dentate gyrusEpendymocytesMicrogliocytesOligodendrogliocytes 10. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #13It has a high propensity to infiltrate the leptomeninges, since most arise in the cortexMicrocalcifications are helpful to the diagnosis, but are present in only 20 % of casesClear cytoplasm due to glycogen accumulation is typical Most are WHO Grade II; however, some can be WHO Grade IV If identified, losses of 1p and 19q indicate better response to treatment 11. Which of the following is true regarding the anomaly depicted in the image? Neuropathology - Part 1, Question #3It occurs due to problems within the 3rd month of gestationIt is usually associated with iris abnormalitiesIt is due to hindbrain abnormalitiesSpinal cord is unaffectedCerebellum, brain stem and pituitary gland may be unaffected 12. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #12 Neuropathology - Part 1, Question #12It is a relatively well-circumscribed tumor, rendering gross total resection possible Typical gross appearance is a solid, well-circumscribed mass It typically occurs in the cerebral hemispheres in the elderlyIt is considered as a WHO Grade II tumor In spite of gross total resection, the prognosis is grim 13. The image is from the temporal lobe of a 5-year-old. This process: Neuropathology - Part 1, Question #5Typically involves the temporal lobe Causes temporary neurological deficits that leads to death within a period of 8 to 12 yearsRequires electron microscopic examination for definitive diagnosisProduces a granulomatous reaction in most casesIs of unknown etiology 14. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?Multiple sclerosis ToxoplasmosisCryptococcosisGlioblastomaChronic lymphocytic leukemia 15. Which of the following is correct regarding the brain tumor shown in the picture? Neuropathology - Part 1, Question #14Losses of 22p is the most common genetic alterationThe most common location is the pineal region of young adultsThis is an undifferentiated tumor, although neuronal and glial markers can be expressedThis is a highly malignant tumor with 5-year survival rate of less than 10%It has a high propensity to infiltrate throughout the brain parenchyma Loading... Share this:TwitterWhatsAppFacebookEmailPrintLinkedIn Related
