Neuropathology – 01

Author: Murat Gokden, M.D.

Make sure to subscribe to PathMD to stay up to date with new content and features!!

1. Which of the following is correct regarding the brain tumor shown in the picture?

This is an undifferentiated tumor, although neuronal and glial markers can be expressed

Losses of 22p is the most common genetic alteration

This is a highly malignant tumor with 5-year survival rate of less than 10%

It has a high propensity to infiltrate throughout the brain parenchyma

The most common location is the pineal region of young adults

2. The lesion shown in the image is from the brain of a 35-year-old, otherwise healthy woman. Which of the following is correct?

It is a rare disorder in this age group

Presents with typical initial neurological signs and symptoms

It is characterized by multiple lesions of various ages

It most commonly involves basal ganglia

It is a dysmyelinating process

3. Which of the following is correct regarding the central nervous system tumors?

Biologic behavior does not necessarily correlate with histology

Supratentorial tumors are common in children

Meningioma is the most common primary brain tumor

The annual incidence is 2/100,000 for intracranial tumors

Hematogenous spread is common in high grade tumors due to vascular proliferation

4. Which of the following types of meningioma has the worst prognosis based on histological features?

Chordoid

Fibroblastic

Metaplastic

Rhabdoid

Secretory

5. Based on this image, this process:

Is a specific form of viral encephalopathy

Is primarily sporadic

Is highly contagious among medical personnel

Evolves within a span of decades, with eventual death

Is difficult to suspect due to ill-defined clinical picture

6. Which of the following is true regarding the anomaly depicted in the image?

Cerebellum, brain stem and pituitary gland may be unaffected

It is usually associated with iris abnormalities

It is due to hindbrain abnormalities

Spinal cord is unaffected

It occurs due to problems within the 3rd month of gestation

7. The microscopic picture shows the entorhinal cortex from the autopsy of a 75-year-old woman. Which of the following is true regarding this process?

This feature is pathognomonic for this disease process

Most common location for this finding is cerebellum

Gross examination of the brain rarely provides any clues

Definitive diagnosis is by autopsy

It presents with rapidly progressing dementia

8. A 40-year-old HIV-positive man was found to have multiple periventricular white matter lesions. Which of the following is most likely?

Multiple sclerosis

Glioblastoma

Cryptococcosis

Toxoplasmosis

Chronic lymphocytic leukemia

9. Which of the following is true regarding acute neuronal injury?

It can be reversible if detected by brain biopsy

Red neurons can be seen as early as 2 hours after injury

Eosinophilic neuronal necrosis is the earliest light microscopic sign

It represents the typical injury pattern associated with toxic-metabolic insults

Healing neurons can be identified as chromatolytic

10. Which of the following is correct regarding the brain tumor shown in the picture?

Most are WHO Grade II; however, some can be WHO Grade IV

Clear cytoplasm due to glycogen accumulation is typical

It has a high propensity to infiltrate the leptomeninges, since most arise in the cortex

Microcalcifications are helpful to the diagnosis, but are present in only 20 % of cases

If identified, losses of 1p and 19q indicate better response to treatment

11. Which of the following is correct regarding the brain tumor shown in the picture?

It typically occurs in the cerebral hemispheres in the elderly

It is considered as a WHO Grade II tumor

It is a relatively well-circumscribed tumor, rendering gross total resection possible

Typical gross appearance is a solid, well-circumscribed mass

In spite of gross total resection, the prognosis is grim

12. A 64-year-old man died as a result of an assault, which involved blunt trauma to the head by a baseball bat, after remaining comatose for two days. The lesion shown in this image:

Is a remote intraparenchymal hematoma secondary to trauma

An organized abscess cavity

Is an acute hemorrhage

Is a remote infarct with hemorrhagic component

Is encephalomalacia due to trauma

13. A 74-year-old man died as a result of lobar pneumonia. At autopsy, cerebellum showed atrophy of the vermis. This condition:

Predominantly affects granule cell layer

Can lead to cerebellar dysfunction in about 20% of cases

Is the result of chronic methanol intoxication

Is the result of an acute intoxication

Is reversible with intensive therapy

14. Which of the following cell types originate outside the central nervous system?

Oligodendrogliocytes

Microgliocytes

Astrocytes

Neurons of the dentate gyrus

Ependymocytes

15. The image is from the temporal lobe of a 5-year-old. This process:

Is of unknown etiology

Produces a granulomatous reaction in most cases

Requires electron microscopic examination for definitive diagnosis

Typically involves the temporal lobe

Causes temporary neurological deficits that leads to death within a period of 8 to 12 years

Share this:

Related