PathMD Quizes, Neuropathology Neuropathology – 02 October 29, 2017 peferguson Author: Murat Gokden, M.D. Make sure to subscribe to PathMD to stay up to date with new content and features!! 1. While walking home after a party where he consumed five cans of beer, a previously healthy 28 year-old man fell and hit his head on the curb. He got up and went home. Later that night, he became unconscious and was brought to the emergency room by his roommate. Physical exam showed swelling of left temporalparietal area. What is the most likely explanation to his condition?Right meningeal artery rupture Rupture of an anterior communicating artery aneurysmLeft cerebral artery rupture Previously asymptomatic bacterial meningitis Left meningeal artery rupture 2. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2It is associated with an autosomal-recessive disorder Bilateral schwannomas are also present in volving the 8th. nerve It is associated with one of the rarest form of genetic disorders It has a higher rate of progression to malignancy compared to general population It is associated with an abnormality in 22q 3. Which of the following is true regarding pituitary adenomas?Invasive adenomas have high probability of distant metastasesPituitary apoplexy is a postpartum neurosurgical emergency Growth hormone adenoma is the most common type Nelson syndrome is associated with gonadotroph adenomas Reticulin stain is a very useful technique for the differential diagnosis of normal pituitary gland vs. hyperplasia vs. adenoma 4. Which of the following pairs is correct?Adrenoleukodystrophy- long chain fatty acids Kerns- Sayre syndrome- mitochondrial tRNA Metachromatic leukodystrophy- arylsulfatase A Vitamin B1 deficiency- subacute combined degenration of the spinal cord Amyotrophic lateral sclerosis- trinucleotide repeats 5. Duret hemorrhages:are the most common cause of aqueductal stenosis are seen in midbrain and ponsoccur in association with subfalcine herniationare secondary to middle meningeal artery tearsaccompany cerebellar mass lesions 6. Which of the following is correct regarding hypertensive central nervous system hemorrhage?periventricular white matter is the preferred site for hemorrhageCharcot-Bouchard aneurysms are thought to be the site of hemorrhage it comprises approximately 1/3 of all intraparenchymal brain hemorrhagesit is the second most common cause of subdural hemorrhage many cases are associated with congophilic angiopathy 7. Which of the following is true regarding the lesion shown in the picture? Neuropathology Set 2 Neuropathology Set 21p/19q losses indicate worse prognosis It is usually seen in the temporal lobe Spinal cord is the most common location in childrenGFAP has a peculiar perinuclear positivityCerebrospinal fluid dissemination is common 8. Which of the following is correct regarding HIV and central nervous system?diagnostic feature is intense lymphocytic infiltrates in the brain parenchyma and in the leptomeningesopportunistic infections are more commonly seen in the pediatric patient population spinal cord involvement presents as transverse myelitis due to opportunistic Herpes virus infectionapproximately 60% of AIDS patients develop neurologic dysfuntion in the course of their diseaseCJD caused by opportunistic JC virus infection is a rare but serious complication 9. Which of the following is true regarding the disease shown in the picture? Neuropathology Set 2it may result in hydrocephaluscerebrospinal fluid shows increased lymphocytes and normal glucose levelS. pneumoniae is the most common cause in adolescents E. coli is the most common cause in the elderly it represents diffuse involvement of meninges by malignancy 10. A 29 year old man was found dead in the street. Autopsy showed hemorrhage under occipital scalp, and contusions of both occipital poles. Which of the following is the most likely explanation?Metastatic lung cancer secondary to heavy smoking Intracranial hemorrhage secondary to hypertensionHe was previously strangled to death and later the body was dumped in a remote street, at which time his head his the concrete pavement He was attacked and was hit on the back of his head by a baseball bat Slipped and fell on his back, hitting his head to concrete pavement 11. Which of the following lesions may be found together with the lesion shown in the picture? (SEGCA) Neuropathology Set 2 Neuropathology Set 2Cardiac rhabdomyoma Renal cell carcinoma GlioblastomaPericardial cyst Subungual angioma 12. Which of the following is true regarding the lesion in this picture? Neuropathology Set 2It usually presents as a highly infiltrative tumor, but paradoxically has a good prognosis It is typically located in the brainstem It may be associated with renal cell carcinoma Its immunophenotype is essentially identical to renal cell carcinoma in many cases It is a highly malignant brain tumor with frequent dissemination to cerbrospinal axis 13. Which of the following is true regarding the disease process shown in the picture? Neuropathology Set 2Structures with similar name, but with different microscopic appearance can be seen in cortical neurons and are easily demonstrated by synuclein immunohistochemistry This disease most commonly involves ageing neurons with lipofucsin pigment This disease can easily be suspected in neonates by gross examinationThis picture is most likely from caudate nucleus Increase in serotonin levels is the major abnormality 14. Which of the following is correct regarding the lesion shown in this picture? Neuropathology Set 2bleeding is typically associated with incipient leakage It is the most common cause of subarachnoid hemorrhageit is usually located at the bending points of arteries The most common location is posterior cerebral artery branches It is the second most common type of intracranial aneurysm 15. Which of the following is true regarding neursyphilis?Meningovascular form is associated with obliterative endarteritis of the meninges Tabes dorsalis is the type that leads to dementia Neurosyphilis occurs in approximately half of untreated and 10% of treated patients It occurs in the secondary stage of the disease Paretic neurosyphilis is aseptic and is an immune reaction to bacterial components Loading... Share this:TwitterWhatsAppFacebookEmailPrintLinkedIn Related
