1. A 4,000 gram spleen was removed from a man and has the histology presented for this case in the images below. Special stains were performed. The cells of interest were positive for CD68 and negative for S-100, CD1a, and PAS. Based on these findings, the best diagnosis is:

2. These images are from the spleen of a 30 y/o pregnant patient. The spleen weighed 2,000 grams. Stains for AFB and fungi were negative. The best diagnosis is:

3. The images for this case are from a 1,000 gram spleen from a 75 year old man. Special stains were positive for CD45 and CD20, but negative for CD3 and CD15. Based on these findings, the best diagnosis is:

4. The images for this case come from an elderly female with a history of an autoimmune disorder. The spleen was 1,500 grams and noted to have “tumor nodules”. Based on the findings, the best diagnosis is:

5. Images for this case come from a spleen in a 60 year old male with a ruptured spleen. Special stains showed positivity for CD20, bcl-1, and CD43. Based on these findings, the best diagnosis is:

6. These images are of a 1,000 gram spleen from a patient with multiple episodes of hemolysis resistant to steroids. Based on the images and the patient’s history, the best diagnosis is:

7. The images for this case come from a 60 year old man with an enlarged spleen and a hilar mass. Based on the information, the best diagnosis is:

8. The images associated with this case are from a moderately enlarged spleen in an individual with a WBC count greater than 150,000. The flow cytometry profile showed the population to express CD13, CD33, and CD117. Based on the morphology and flow cytometry, the best diagnosis is: