Immunophenotypic Expression Pattern
|
Marker
|
Comment
|
|
Variably Positive (up to a 1/3rd may be Negative)
|
|
|
Positive in >50% of cases.
|
|
|
Positive by definition. Nuclear and cytoplasmic expression is c/w t(2;5). ALK may show nuclear, membraneous, or cytoplasmic localization dependent upon what type of translocation is involved.
|
|
|
Positive
|
|
|
Positive (70%)
|
|
|
Negative in >75% of cases (rare +)
|
|
|
Positive (70%)
|
|
|
Negative (rare +)
|
|
|
+/- (70%)
|
|
|
Negative (rare +)
|
|
|
Negative
|
|
|
Positive (majority)
|
|
|
EBV (EBER)
|
Negative
|
|
Perforin
|
Usually Positive
|
|
Usually Positive
|
|
|
TIA-1
|
Positive
|
|
Negative
|
|
|
Negative
|
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011. pp. 312-19.