Organ Systems, Bone Marrow, WHO Classification, MPN, Hematopathology

MF2 – Reticulin Fibrosis

Diffuse increase of reticulin fibers with increased density and numerous intersections.  Focal bundles of thick fibers.

Photomicrographs
Hematopathology - Part 7, Case #6
Hematopathology – MF2 reticulin fibrosis.  Could be MF3 if there was evidence of collagen fibrosis.
References
Swerdlow SH, Campo E, Harris, NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):  WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition). IARC: Lyon 2017
 
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127: 2391–2405. doi:10.1182/blood-2016-03-643544