MF3 – Reticulin Fibrosis

Diffuse increase of reticulin fibers with increased density and numerous intersections.  Increased thick bundles of fibers consistent with collagen fibrosis.  Osteosclerosis usually present.


Photomicrographs
Reticulin - MF3 fibrosis
Reticulin – MF3 fibrosis
Reticulin - MF3 fibrosis
Reticulin – MF3 fibrosis
Trichrome - MF3 fibrosis
Trichrome – MF3 fibrosis
Trichrome - MF3 fibrosis
Trichrome – MF3 fibrosis
References
Swerdlow SH, Campo E, Harris, NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):  WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition). IARC: Lyon 2017
 
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127: 2391–2405. doi:10.1182/blood-2016-03-643544