T-Acute Lymphoblastic Leukemia/Lymphoma
Immunophenotypic Expression Pattern
|
Stain
|
Comment
|
|
+/-
|
|
|
Usually Positive
|
|
|
Positive
|
|
|
+/-
|
|
|
Usually Positive
|
|
|
Positive
|
|
|
+/-
|
|
|
30% +
|
|
|
Positive
|
|
|
Positive
|
|
|
Subset +
|
|
|
Negative
|
|
|
May be positive in up to 10% of cases.
|
|
|
CD13, CD33
|
Positive in 19-32% of cases.
|
Only CD7 and cytoplasmic CD3 are considered lineage specific of the T-cell CD markers (CD1a, CD2, CD3, CD4, CD5, CD7, and CD8).
CD4 and CD8 co-expression is not specific and may be seen in other T-cell disorders such as T-PLL. CD10 expression may also be seen in peripheral T-cell lymphomas (e.g. angioimmunoblastic T-cell lymphoma).
References
Parker, A., et. al. “Best Practice in Lymphoma Diagnosis and Reporting.” British Committee for Standards in Haematology, Royal College of Pathologists. April, 2010.
Hematopathology. [edited by] Jaffe, ES. 1st. ed. Elsevier, Inc. © 2011.